Z2626
Zaragozic acid A trisodium salt
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
Sinónimos:
L-694,599, Squalestatin
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Fórmula empírica (notación de Hill):
C35H43O14Na3
Número CAS:
Peso molecular:
756.68
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
biological source
microbial
Quality Level
assay
≥95% (HPLC)
form
lyophilized powder
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
Application
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Biochem/physiol Actions
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Legal Information
Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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