900275
(t-Bu)PhCPhos
95%, powder or crystals
别名:
2-[(tert-Butyl)phenylphosphino]-2′,6′-bis(N,N-dimethylamino)biphenyl
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关于此项目
经验公式（希尔记法）:
C26H33N2P
化学文摘社编号:
分子量:
404.53
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
95%
Form:
powder or crystals
产品名称
(t-Bu)PhCPhos, 95%
Quality Segment
product line
Buchwald Ligand
assay
95%
form
powder or crystals
reaction suitability
reagent type: catalyst
reaction type: Cross Couplings, reagent type: ligand
mp
112 °C
functional group
phosphine
SMILES string
P(C(C)(C)C)(c2c(cccc2)c3c(cccc3N(C)C)N(C)C)c1ccccc1
InChI
1S/C26H33N2P/c1-26(2,3)29(20-14-9-8-10-15-20)24-19-12-11-16-21(24)25-22(27(4)5)17-13-18-23(25)28(6)7/h8-19H,1-7H3
InChI key
HTHOMNNVAUPLKK-UHFFFAOYSA-N
Application
(t-Bu)PhCPhos is the Pd G3 complex, from the Buchwald group offers best-in-class performance in the arylation of sterically hindered primary amines.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Paula Ruiz-Castillo et al.
Journal of the American Chemical Society, 137(8), 3085-3092 (2015-02-05)
We report the Pd-catalyzed arylation of very hindered α,α,α-trisubstituted primary amines. Kinetics-based mechanistic analysis and rational design have led to the development of two biarylphosphine ligands that allow the transformation to proceed with excellent efficiency. The process was effective in