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07386

辅酶 Q10

analytical standard

别名:

Q-10, 辅酶Q10, 辅酶Q50

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关于此项目

经验公式（希尔记法）:
C59H90O4
化学文摘社编号:
303-98-0
分子量:
863.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329748422
EC Number:
206-147-9
Beilstein/REAXYS Number:
1900141
MDL number:
MFCD00042919
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grade

analytical standard

Quality Level

100

assay

≥97.5% (HPLC)

form

powder

shelf life

limited shelf life, expiry date on the label

impurities

≤1.0% water

color

faint yellow to dark orange

mp

49 °C

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

General description

辅酶Q10是线粒体呼吸链中的中心电子载体，来源于食物摄入以及内源合成。它通常以还原形式起作用，可防止生物膜和血清低密度脂蛋白（LDL）中的脂质过氧化。它往往可以保护线粒体膜蛋白和DNA免受脂质过氧化引起的氧化损伤。

Application


  • Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice：研究表明辅酶Q10可通过抗氧化机制和炎症调节有效减轻心脏损伤，提供人体治疗参考(Antar et al., 2024)。

  • Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10：研究辅酶Q10及牛磺酸如何缓解氯丙嗪所致血液不良反应，体现它对付精神治疗副反应的作用(Obukohwo et al., 2024)。

  • Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms：讨论辅酶Q10在肌肉健康中的作用，尤其它可通过线粒体支持防止肌肉萎缩并增强细胞能量代谢，与运动医学和衰老研究紧密相关(Shen et al., 2024)。

  • Identification of a family of species-selective complex I inhibitors as potential anthelmintics：本文与辅酶Q10间接相关，研究重点涉及的线粒体功能，与辅酶Q10在同类通路上的作用有关。代表在寄生虫学和传染病领域的新应用意义(Davie et al., 2024)。

Other Notes

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP5250
BCCM8079
BCCL4255
BCCL4259
BCCJ0835

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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
Gian Paolo Littarru et al.
Nutrition (Burbank, Los Angeles County, Calif.), 26(3), 250-254 (2009-11-26)
The fundamental role of coenzyme Q(10) (CoQ(10)) in mitochondrial bioenergetics and its well-acknowledged antioxidant properties constitute the basis for its clinical applications, although some of its effects may be related to a gene induction mechanism. Cardiovascular disease is still the
Igor Pravst et al.
Critical reviews in food science and nutrition, 50(4), 269-280 (2010-03-20)
Coenzyme Q10 (CoQ(10)) is an effective natural antioxidant with a fundamental role in cellular bioenergetics and numerous known health benefits. Reports of its natural occurrence in various food items are comprehensively reviewed and critically evaluated. Meat, fish, nuts, and some
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