N8878
萘啶酸
≥98%
别名:
1,4-二氢-1-乙基-7-甲基-1,8-萘啶-4-酮-3-羧酸, 1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸
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关于此项目
经验公式（希尔记法）:
C12H12N2O3
化学文摘社编号:
分子量:
232.24
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-864-7
Beilstein/REAXYS Number:
750515
MDL number:
biological source
synthetic
Quality Level
assay
≥98%
form
powder
mp
227-229 °C (lit.)
solubility
chloroform: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12
InChI
1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
InChI key
MHWLWQUZZRMNGJ-UHFFFAOYSA-N
General description
化学结构：喹诺酮
Application
用于调节（抑制）细菌DNA促旋酶依赖性过程，如DNA聚合、（ATP依赖性）tDNA超螺旋化和染色体断裂。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Robert J Commons et al.
The Medical journal of Australia, 196(5), 332-336 (2012-03-22)
To determine incidence and trends in antibiotic resistance in Australian Salmonella enterica subspecies enterica serovars Typhi (S. Typhi) and Paratyphi (S. Paratyphi) isolates over the past 26 years. A retrospective analysis of consecutive microbiologically confirmed enteric fever isolates. All S.
Edel O'Regan et al.
Antimicrobial agents and chemotherapy, 53(3), 1080-1087 (2008-12-24)
Mechanisms of antibiotic resistance were examined in nalidixic acid-resistant Salmonella enterica serovar Enteritidis field isolates displaying decreased susceptibility to ciprofloxacin and in in vitro-derived ciprofloxacin-resistant mutants (104-cip and 5408-cip). All field isolates harbored a single gyrA mutation (D87Y). Deletion of
Suzanne Bialek et al.
Antimicrobial agents and chemotherapy, 54(10), 4373-4378 (2010-08-04)
Cross-resistance to cefoxitin (FOX), chloramphenicol (CMP), and quinolones (nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella pneumoniae. The potential impact of this multidrug resistance (MDR) on the virulence of K. pneumoniae was