53467
2,3-二油氧基-1-（二甲氨基）丙烷
≥98.0% (TLC)
别名:
1,2-二油氧基-3-（二甲氨基）丙烷, N,N-二甲基-2,3-双[(9Z)-9-十八碳烯-1-基氧基]-1-丙胺, DODMA
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关于此项目
经验公式（希尔记法）:
C41H81NO2
化学文摘社编号:
分子量:
620.09
UNSPSC Code:
12352211
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
10139013
biological source
synthetic
Quality Level
assay
≥98.0% (TLC)
form
liquid
functional group
amine, ether
lipid type
cationic lipids
storage temp.
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC
InChI
1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-
InChI key
GLGLUQVVDHRLQK-WRBBJXAJSA-N
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids.
Heyes, J., et al.
J. Controlled Release, 107, 276-287 (2005)
Lloyd B Jeffs et al.
Pharmaceutical research, 22(3), 362-372 (2005-04-20)
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution
Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery.
Yujing Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 371-381 (2016-10-18)
Microfluidic systems can accelerate clinical translation of nanoparticles due to their ability to generate nanoparticles in a well-controlled and reproducible manner. In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs)