P4562
丙酮酸钠
powder, BioXtra, suitable for mouse embryo cell culture
别名:
α酮基丙酸 钠盐, 2-氧代丙酸 钠盐, 丙酮酸 钠盐
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关于此项目
线性分子式:
CH3COCOONa
化学文摘社编号:
分子量:
110.04
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
204-024-4
Beilstein/REAXYS Number:
3568341
MDL number:
Assay:
≥99%
Form:
powder
product line
BioXtra
Quality Level
assay
≥99%
form
powder
technique(s)
cell culture | embryo: suitable
mp
>300 °C (lit.)
solubility
H2O: 100 mg/mL
storage temp.
2-8°C
SMILES string
[Na+].CC(=O)C([O-])=O
InChI
1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1
InChI key
DAEPDZWVDSPTHF-UHFFFAOYSA-M
General description
丙酮酸盐(pyruvate)，糖酵解通路的终产物，是丙酮酸(pyruvic acid)的阴离子形式。
Application
丙酮酸钠可用于：
- 作为精子培养Ca2+ + N三羟甲基甲胺基乙磺酸(TES)–NaCl溶液的补充剂
- 作为TCM-199 hepes改良溶液的补充剂，用于卵丘卵母细胞复合体(COC′s)培养
- 作为杜氏改良Eagle培养基(DMEM)补充剂，用于培养小鼠原代肝细胞(MPH)，并用于腹腔注射禁食小鼠进行葡萄糖生成评估
Biochem/physiol Actions
丙酮酸钠主要用作培养基和肉汤组分。丙酮酸钠的抗氧化和抗炎作用可用于治疗过敏性鼻炎。丙酮酸钠还能用作乳酸中毒治疗的新药。
细胞将丙酮酸钠作为一种易于获取的碳水化合物来源。此外，它还参与氨基酸代谢并启动Kreb′循环。丙酮酸钠减弱体外氧化应激。 对于大多数细胞培养应用，应将100 mM溶液按1:100比例稀释。 该产品已被认证可用于小鼠胚胎培养。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1B
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
用于转基因小鼠胚胎培养的小鼠胚胎培养基及经过胚胎培养验证的试剂
Mouse embryo media and embryo validated reagents for transgenic mouse embryo culture
Milli-Q® 系统产出的超纯水不含BPA，适合用于胚胎学研究，最大限度地减少内分泌干扰物的干扰。
相关内容
Product Information Sheet
Rangga Setiawan et al.
Animal reproduction science, 233, 106843-106843 (2021-09-15)
Adenosine triphosphate (ATP) production via glycolysis and oxidative phosphorylation is essential for the maintenance of flagellar motility in sperm; however, the primary energy production pathways supporting fertilization vary among species. Inconsistency in thought exists regarding which pathways maintain ATP production
Maheul Ploton et al.
Journal of hepatology, 69(5), 1099-1109 (2018-07-08)
Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. Hepatic gluconeogenesis is controlled through allosteric regulation of gluconeogenic enzymes and by
Kyle S McCommis et al.
The Biochemical journal, 466(3), 443-454 (2015-03-10)
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely