R0395
Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
别名:
AY 22989, 西罗莫司, 雷帕霉素
选择尺寸
关于此项目
产品名称
Rapamycin 来源于吸水链霉菌, ≥95% (HPLC), powder
Quality Level
assay
≥95% (HPLC)
form
powder
color
off-white
solubility
ethanol: 2 mM, DMSO: soluble
antibiotic activity spectrum
fungi, yeast
mode of action
enzyme | inhibits, protein synthesis | interferes
storage temp.
−20°C
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Gene Information
human ... FKBP1A(2280)
General description
Application
- 处理BV2细胞或BV2- lc3细胞，进行自噬实验
- 作为自噬激活剂，用于转染FOXO3小干扰RNA慢病毒载体（siFOXO3）的骨髓间充质干细胞（BM-MSCs），以研究Forkhead Box O3（FOXO3）对BM-MSC
- 自噬的影响，以预孵育绒毛并抑制雷帕霉素复合物1 （mTORC1）信号传导的哺乳动物靶点
Biochem/physiol Actions
Other Notes
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signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.