SML0749
SC79
≥97% (NMR), AKT activator, powder
别名:
2-氨基-6-氯-α-氰基-3-（乙氧基羰基）-4H-1-苯并吡喃-4-乙酸乙酯
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
产品名称
SC79, ≥97% (NMR)
Quality Level
assay
≥97% (NMR)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
Clc1cc2c(cc1)OC(=C(C2C(C(=O)OCC)C#N)C(=O)OCC)N
InChI
1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChI key
DXVKFBGVVRSOLI-UHFFFAOYSA-N
Application
SC79 可在蛋白质印迹分析中作为阳性对照，用于测定 Akt 的磷酸化程度以及激活已经被氯化尼替丁（一种天然生物活性生物碱）抑制的 Akt。
Biochem/physiol Actions
SC79 是一种 AKT 激活剂。
SC79 是一种 AKT 激活剂。SC79 与 Akt 的 plecktrin 同源性（PH）结构域结合，其模拟 PtdIns（3，4，5）P3 的结合以诱导 Akt 中的构象变化，其增强磷酸化和活化。SC79 在基于细胞的测定中诱导胞质 Akt 信号传导，并防止中风小鼠模型中的神经元死亡。
Still not finding the right product?
Explore all of our products under SC79
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offer many products related to PKB/Akt for your research needs.
Silver nanoparticles suppresses brain-derived neurotrophic factor-induced cell survival in the human neuroblastoma cell line SH-SY5Y.
Park J H, et al.
Journal of Industrial and Engineering Chemistry, 47 , 62-73 (2017)
Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
Zhang, et al.
Bioengineered, 13, 12350-12364 (2022)
Rongrong Huang et al.
Neoplasma (2021-10-15)
According to our previous research, phycocyanin (PC) could inhibit pancreatic tumor growth obviously. However, little is known about the effects of phycocyanin on pancreatic tumor metastasis. This study was aimed to investigate whether phycocyanin inhibits pancreatic cancer cells' metastasis and