72345
ニコチンアミド
synthetic, ≥98.5% (HPLC), PARP inhibitor, powder
別名:
ナイアシンアミド, ニコチン酸アミド, ビタミンB3, ビタミンPP, ピリジン-3-カルボン酸アミド
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C6H6N2O
CAS番号:
分子量:
122.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-713-4
MDL number:
Beilstein/REAXYS Number:
383619
Assay:
≥98.5% (HPLC)
Form:
powder
製品名
ニコチンアミド, ≥98.5% (HPLC)
biological source
synthetic
Quality Segment
assay
≥98.5% (HPLC)
form
powder
color
colorless to white
mp
128-131 °C
SMILES string
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
General description
Nicotinamide is synthesized in the liver from nicotinic acid. It is also produced as a result of nicotinamide adenine dinucleotide (NAD+) hydrolysis.
Application
Nicotinamide has been used:
- as a precursor to study its effect on nicotinamide adenine dinucleotide (NAD) concentration in NAD-deficient mammalian mitochondria
- as an inhibitor of sirtuin (SIRT) family of deacetylases in in vitro serine hydroxymethyltransferase 2 (SHMT2) deacetylation assay
- to study its effect on ischemia-reperfusion (I-R) injury-induced cell death in ptenαm/m mice
Biochem/physiol Actions
ニコチンアミドは、ビタミンB3とPARPインヒビターのアミド誘導体です。
Nicotinamide serves as a precursor for β-nicotinamide adenine dinucleotide (NAD+) coenzyme production. It is involved in the synthesis of NAD+ phosphate (NADP+). It also regulates the mechanism of cell survival and cell death. Fatigue, skin pigmentation, decreased appetite and mouth ulcers are indications of nicotinamide deficiency. Its chronic deficiency can lead to pellagra. Nicotinamide is known to show protective effects on oxidative stress.
Still not finding the right product?
Explore all of our products under ニコチンアミド
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves