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533869 Sigma-2 Receptor Antagonist, CT01344

A cell-permeable, selective antagonist of Sigma-2 receptor. Blocks Abeta effects on membrane trafficking (EC₅₀ = 8.7 µM) and displaces Abeta binding to neurons (EC₅₀ = 3.9 µM).

Sigma-2 Receptor Antagonist, CT01344: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: (R)-4-(3,4-dichlorophenyl)-N-(4-(trifluoromethyl)benzyl)butan-2-amine, PGRMC-1 Receptor Antagonist, CT01344

Primary Target: Sigma-2
533869
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₈H₁₈Cl₂F₃N
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, benzyl amine compound that can cross the blood-brain barrier and act as a selective antagonist of Sigma-2/progesterone receptor membrane component 1 (PGRMC1) receptor. Shown to competitively displace selective radioligand (3H-DTG) from homogenates of human B cell lines (Ki = 48 nM). Effectively blocks the effects of Abeta on membrane trafficking (EC50 = 8.7 µM) and displaces Abeta binding on cultured neurons (EC50 = 3.9 µM). It can also reverse Abeta oligomer-mediated trafficking deficits (EC50 = 7.3 µM) and restore normal synaptic function and cognitive abilities in a murine model of Alzheimer′s disease (10 - 30 mg/kg. p.o. over a period of 5.5 months). Shown to be effective when added either 1 hour prior to or 1 hour after Abeta oligomer preparations.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533869
      Brand Family Calbiochem®
      Synonyms(R)-4-(3,4-dichlorophenyl)-N-(4-(trifluoromethyl)benzyl)butan-2-amine, PGRMC-1 Receptor Antagonist, CT01344
      DescriptionSigma-2 Receptor Antagonist, CT01344
      References
      ReferencesIzzo, P.M., et al. 2014. Plos One. 9, e111898.
      Product Information
      FormLight yellow oil
      Hill FormulaC₁₈H₁₈Cl₂F₃N
      Chemical formulaC₁₈H₁₈Cl₂F₃N
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSigma-2
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      533869 0

      Documentation

      Sigma-2 Receptor Antagonist, CT01344 MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Izzo, P.M., et al. 2014. Plos One. 9, e111898.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2016 JSW
      Synonyms(R)-4-(3,4-dichlorophenyl)-N-(4-(trifluoromethyl)benzyl)butan-2-amine, PGRMC-1 Receptor Antagonist, CT01344
      DescriptionA cell-permeable, benzyl amine compound that can cross the blood-brain barrier and act as a selective antagonist of Sigma-2/progesterone receptor membrane component 1 (PGRMC1) receptor. Shown to competitively displace selective radioligand (3H-DTG) from homogenates of human B cell lines (Ki = 48 nM). Effectively blocks the effects of Abeta on membrane trafficking (EC50 = 8.7 µM) and displaces Abeta binding on cultured neurons (EC50 = 3.9 µM). It can also reverse Abeta oligomer-mediated trafficking deficits (EC50 = 7.3 µM) and restore normal synaptic function and cognitive abilities in a murine model of Alzheimer′s disease (10 - 30 mg/kg. p.o. over a period of 5.5 months). Shown to be effective when added either 1 hour prior to or 1 hour after Abeta oligomer preparations.
      FormLight yellow oil
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₈Cl₂F₃N
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIzzo, P.M., et al. 2014. Plos One. 9, e111898.