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504844 7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt

Primary Target: NMDA receptors
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1263094-00-3C₁₀H₅ClNNaO₃

Products

Catalogue NumberPackaging Qty/Pack
5.04844.0001 玻璃瓶 10 mg
Description
OverviewA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
Catalogue Number504844
Brand Family Calbiochem®
Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
References
ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
Stone, W., et al. 2012. FEBS J. 279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
Product Information
CAS number1263094-00-3
FormWhite solid
Hill FormulaC₁₀H₅ClNNaO₃
Chemical formulaC₁₀H₅ClNNaO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>0.56 →M
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.04844.0001 04055977243611

Documentation

7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
Stone, W., et al. 2012. FEBS J. 279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2013 JSW
Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
DescriptionA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
FormWhite solid
CAS number1263094-00-3
Chemical formulaC₁₀H₅ClNNaO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
Stone, W., et al. 2012. FEBS J. 279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.