Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

DR1001 Anti-8-Hydroxyguanosine Goat pAb

This Anti-8-Hydroxyguanosine Goat polyclonal antibody detects 8-Hydroxydeoxyguanosine in Alzheimer's disease brain tissue. It is validated for use in ELISA and with paraffin sections.

Anti-8-Hydroxyguanosine Goat pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-8-OHG, Anti-8-oxo-G

View Products on Sigmaaldrich.com
DR1001
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
A Broad Range Of SpeciesGtPolyclonal Antibody

Products

Catalogue NumberPackaging Qty/Pack
DR1001-100ULCN 塑膠安瓿;塑膠針藥瓶 100 ul
Description
OverviewRecognizes 8-Hydroxydeoxyguanosine in Alzheimer's disease brain tissue.
Catalogue NumberDR1001
Brand Family Calbiochem®
SynonymsAnti-8-OHG, Anti-8-oxo-G
Application Data
Detection of 8-hydroxyguanosine in oxidized RNA by staining paraffin sections. Sample: Alzheimer's disease brain tissue formalin-fixed, paraffin-embedded and left untreated (left panel) or pretreated with 10 µg/ml proteinase K for 40 min at 37°C (right panel). Primary antibody: Anti-8-Hydroxyguanosine Goat pAb (Cat. No. DR1001) (1:200). Detection: DAB.
References
ReferencesAbe, T., et al. 2003. Neurosci. Lett. 336, 105.
Parker, A.R., et al. 2002. Cancer Res. 62, 7230.
Product Information
FormLiquid
FormulationUndiluted serum.
Positive controlAlzheimer’s disease brain tissue
PreservativeNone
Quality LevelMQ100
Applications
Application ReferencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.
Key Applications Paraffin Sections
Application NotesELISA (≥1:250,000)
Paraffin Sections (≥1:200, proteinase K pre-treatment recommended; see figure legend, see application references)
Application CommentsDoes not cross-react with other naturally occurring nucleotides. Antibody should be titrated for optimal results in individual systems.
Biological Information
Immunogen8-Hydroxyguanosine
HostGoat
IsotypeIgG
Species Reactivity
  • A Broad Range Of Species
Antibody TypePolyclonal Antibody
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
DR1001-100ULCN 04055977225884

Documentation

Anti-8-Hydroxyguanosine Goat pAb MSDS

Title

Safety Data Sheet (SDS) 

Anti-8-Hydroxyguanosine Goat pAb Certificates of Analysis

TitleLot Number
DR1001

References

Reference overview
Abe, T., et al. 2003. Neurosci. Lett. 336, 105.
Parker, A.R., et al. 2002. Cancer Res. 62, 7230.

Citations

Title
  • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-August-2007 RFH
    SynonymsAnti-8-OHG, Anti-8-oxo-G
    ApplicationELISA (≥1:250,000)
    Paraffin Sections (≥1:200, proteinase K pre-treatment recommended; see figure legend, see application references)
    Application Data
    Detection of 8-hydroxyguanosine in oxidized RNA by staining paraffin sections. Sample: Alzheimer's disease brain tissue formalin-fixed, paraffin-embedded and left untreated (left panel) or pretreated with 10 µg/ml proteinase K for 40 min at 37°C (right panel). Primary antibody: Anti-8-Hydroxyguanosine Goat pAb (Cat. No. DR1001) (1:200). Detection: DAB.
    DescriptionGoat polyclonal antibody supplied as undiluted serum. Recognizes 8-hydroxydeoxy-guanosine.
    Background8-Hydroxydeoxy-guanosine is a modified base that occurs in DNA due to attack by reactive oxygen species. Increases in the levels of 8-hydroxyguanosine have been associated with several diseases in humans, such as arteriosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.
    HostGoat
    Immunogen8-Hydroxyguanosine
    IsotypeIgG
    Speciesa broad range of species
    Positive controlAlzheimer’s disease brain tissue
    FormLiquid
    FormulationUndiluted serum.
    PreservativeNone
    CommentsDoes not cross-react with other naturally occurring nucleotides. Antibody should be titrated for optimal results in individual systems.
    Storage Avoid freeze/thaw
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Standard Handling
    ReferencesAbe, T., et al. 2003. Neurosci. Lett. 336, 105.
    Parker, A.R., et al. 2002. Cancer Res. 62, 7230.
    Citation
  • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
    		•
    Application referencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.