Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABC85 Anti-ANGPTL2 Antibody

This Anti-ANGPTL2 antibody is validated for use in WB, IH for the detection of ANGPTL2.

Anti-ANGPTL2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANGPTL2, ARP2 UniProt Number: Q9UKU9
View Products on Sigmaaldrich.com
ABC85
200 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC85
DescriptionAnti-ANGPTL2 Antibody
Alternate Names
  • Angiopoietin-related protein 2
  • Angiopoietin-like protein 2
Background InformationThe protein named Angiopoietin-related protein 2 (ANGPTL2) or Angiopoietin-like protein 2 and encoded by the human gene named ANGPTL2/ARP2 is a secreted protein that is highly expressed in several tissues including the heart, spleen, stomach, colon, ovary and skeletal muscle. ANGPTL2 functions to induce endothelial cell sprouting in preparation for angiogenesis. ANGPTL2 is produced by endothelial cells and ANGPTL2 appears to function as an autocrine in helping to promote the sprouting response. ANGPTL2 also appears to use the same autocrine function in certain cancers and in particular in driving of metastasis. Recent research have demonstrated that tumor cell–derived ANGPTL2 increased in vitro motility and invasion in an autocrine/paracrine manner, conferring an aggressive metastatic tumor phenotype on the cells examined. Thus research is now focused on blocking the function of ANGPTL2 as one possible treatment for metastatic cancers. EMD-Millipore’s Anti-ANGPTL2 rabbit polyclonal antibody has been tested in western blot on mouse small intestine tissue extracts and in paraffin embedded immunohistochemistry on human heart tissue sections.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-ANGPTL2 antibody is validated for use in WB, IH for the detection of ANGPTL2.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ANGPTL2 in human heart sections tissue.
Biological Information
ImmunogenN-Trx, C-6XHis-tagged recombinant protein corresponding to human ANGPTL2.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • ANGPTL2
  • ARP2
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~60 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in transfected HEK293 with ANGPTL2.

Western Blotting Analysis: A 1:250 dilution of this antibody detected ANGPTL2 in 10 µg of transfected HEK293 with ANGPTL2.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC85 04055977122299