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AB3402P Anti-Agouti Related Protein Antibody

Detect Agouti Related Protein using this Anti-Agouti Related Protein Antibody validated for use in ELISA & WB.

Anti-Agouti Related Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Glucose/Glycogen Metabolism Gene Symbol: AGRP, Agrt, ASIP2, MGC118963, AGRT, ART UniProt Number: O00253
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AB3402P
50 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MELISA, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB3402P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Agouti Related Protein Antibody
Alternate Names
  • AGRP
Background InformationAgouti-related peptide-expressing (AgRP) neurons seem to be critical for the acute regulation of eating. The AgRP protein is a strong antagonis of MC3-R and MC4-R and is expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
References
Product Information
FormatAffinity Purified
HS Code3002 15 90
PresentationLiquid in phosphate buffered saline containing 0.1% BSA.
Quality LevelMQ100
Applications
ApplicationDetect Agouti Related Protein using this Anti-Agouti Related Protein Antibody validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesWestern blot: 1-10 μg/mL using ECL.



ELISA: 1:10,000-1:50,000 using 50-100 ng control peptide per well.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenA 15 amino acid peptide near the C-terminus of mouse AGRP (Shutter et al. 1997; Ollmann et al. 1997).
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes AGRP. The immunogen shows no significant sequence homology with Agouti, tubby, tub, TULP1 or TULP2.

SPECIES REACTIVITIES: The immunogen sequence is 85% homologous with human and bovine. Reactivity with other species has not been confirmed.
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryAgouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5' untranslated sequence length.
Gene Symbol
  • AGRP
  • Agrt
  • ASIP2
  • MGC118963
  • AGRT
  • ART
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O00253 # Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
SIZE: 132 amino acids; 14440 Da
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
DOMAIN: SwissProt: O00253 The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
DISEASE: SwissProt: O00253 # Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].
SIMILARITY: Contains 1 agouti domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB3402P 04053252401688

Documentation

Anti-Agouti Related Protein Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Agouti Related Protein Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2399470 2399470
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 3493310 3493310
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 3587999 3587999
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 3810226 3810226
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 4142025 4142025
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 4143282 4143282
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) - 4290101 4290101
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2062322 2062322
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2179344 2179344
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2197187 2197187

Data Sheet

Title
RABBIT ANTI-AGRP (AGOUTI RELATED PROTEIN) AFFINITY PURIFIED POLYCLONAL ANTIBODY