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AB9451 Anti-Metabotropic Glutamate Receptor 8 Antibody

Anti-Metabotropic Glutamate Receptor 8 Antibody detects level of Metabotropic Glutamate Receptor 8 & has been published & validated for use in IH(P).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRM8, GLUR8, mGlu8, MGLUR8, MGC126724, mGluR8, FLJ41058, GPRC1H UniProt Number: O00222
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AB9451
50 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB9451
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Metabotropic Glutamate Receptor 8 Antibody
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Metabotropic Glutamate Receptor 8 Antibody detects level of Metabotropic Glutamate Receptor 8 & has been published & validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry on paraffin embedded tissue sections.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide from the C-terminal domain of human Metabotropic Glutamate Receptor 8.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes Metabotropic Glutamate Receptor 8 [mGluR8].
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.
Gene Symbol
  • GRM8
  • GLUR8
  • mGlu8
  • MGLUR8
  • MGC126724
  • mGluR8
  • FLJ41058
  • GPRC1H
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O00222 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
SIZE: 908 amino acids; 101741 Da
SUBUNIT: Interacts with PRKCABP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: O00222 ## Belongs to the G-protein coupled receptor 3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB9451 04053252732065