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189406 Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

The Aurora Kinase/Cdk Inhibitor, also referenced under CAS 443797-96-4, controls the biological activity of Aurora Kinase/Cdk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621

Primary Target: Aurora Kinase/Cdk
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189406
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
443797-96-4C₁₅H₁₂F₂N₆O₃S • CH₃CN

Products

Catalogue NumberPackaging Qty/Pack
189406-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
Catalogue Number189406
Brand Family Calbiochem®
Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
References
ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
Lin R., et al. 2005. J. Med. Chem. 48, 4208.
Product Information
CAS number443797-96-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAurora Kinase/Cdk
Primary Target IC<sub>50</sub>11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189406-5MGCN 04055977221756

Documentation

Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem Certificates of Analysis

TitleLot Number
189406

References

Reference overview
Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
Lin R., et al. 2005. J. Med. Chem. 48, 4208.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
DescriptionA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112-514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number443797-96-4
Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
Lin R., et al. 2005. J. Med. Chem. 48, 4208.