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251680 Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Ryanodine receptor
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251680
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
14663-23-1C₁₄H₉N₄O₅ · Na

Products

Catalogue NumberPackaging Qty/Pack
251680-100MGCN 塑膠安瓿;塑膠針藥瓶 100 mg
Description
OverviewA cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.
Catalogue Number251680
Brand Family Calbiochem®
References
ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
Product Information
CAS number14663-23-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₁₄H₉N₄O₅ · Na
Chemical formulaC₁₄H₉N₄O₅ · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRyanodine receptor
Purity≥ 95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMU3875000
Safety Information
R PhraseR: 20/21/22-45

Harmful by inhalation, in contact with skin and if swallowed.
May cause cancer.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
251680-100MGCN 07790788048983

Documentation

Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem Certificates of Analysis

TitleLot Number
251680

References

Reference overview
Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-June-2009 RFH
DescriptionA skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.
FormOrange solid
CAS number14663-23-1
RTECSMU3875000
Chemical formulaC₁₄H₉N₄O₅ · Na
Structure formulaStructure formula
Purity≥ 95% by HPLC
SolubilityAqueous alkaline solutions or DMSO (3 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 2816
ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.