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356310 Glyburide - CAS 10238-21-8 - Calbiochem

A sulfonylurea that selectively blocks ATP-sensitive K+ channels.

Glyburide - CAS 10238-21-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Glybenclamide

Primary Target: ATP-sensitive K+ channels
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
10238-21-8C₂₃H₂₈ClN₃O₅S

Products

Catalogue NumberPackaging Qty/Pack
356310-1GMCN 塑膠安瓿;塑膠針藥瓶 1 gm
Description
OverviewA sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
Catalogue Number356310
Brand Family Calbiochem®
SynonymsGlybenclamide
References
ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Product Information
CAS number10238-21-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₂₈ClN₃O₅S
Chemical formulaC₂₃H₂₈ClN₃O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetATP-sensitive K+ channels
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYS4725200
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
356310-1GMCN 04055977192711

Documentation

Glyburide - CAS 10238-21-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Glyburide - CAS 10238-21-8 - Calbiochem Certificates of Analysis

TitleLot Number
356310

References

Reference overview
Holzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-May-2008 RFH
SynonymsGlybenclamide
DescriptionAntidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).
FormWhite solid
CAS number10238-21-8
RTECSYS4725200
Chemical formulaC₂₃H₂₈ClN₃O₅S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 4478
ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.