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428150 Lavendustin A - CAS 125697-92-9 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase and p60c-src with little effect on protein kinase A or protein kinase C.

Lavendustin A - CAS 125697-92-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355

Primary Target: EGF receptor tyrosine kinase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
125697-92-9C₂₁H₁₉NO₆

Products

Catalogue NumberPackaging Qty/Pack
428150-1MGCN 塑膠安瓿;塑膠針藥瓶 1 mg
Description
OverviewA cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats.
Catalogue Number428150
Brand Family Calbiochem®
Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
References
ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
Product Information
CAS number125697-92-9
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₁₉NO₆
Chemical formulaC₂₁H₁₉NO₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGF receptor tyrosine kinase
Primary Target IC<sub>50</sub>11 nM and 500 nM against EGF receptor tyrosine kinase and p60c-src, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
428150-1MGCN 04055977210545

Documentation

Lavendustin A - CAS 125697-92-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Lavendustin A - CAS 125697-92-9 - Calbiochem Certificates of Analysis

TitleLot Number
428150

References

Reference overview
Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
DescriptionA cell-permeable, reversible, substrate competitive, and potent inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and pp60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 >200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor in rats.
FormOff-white solid
CAS number125697-92-9
Chemical formulaC₂₁H₁₉NO₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO or Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.