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HCYTABM-17K MILLIPLEX® Human Cytokine Autoantibody IgM Kit

The MILLIPLEX® Human Cytokine Autoantibody IgM Panel is a bead-based qualitative assay based on the Luminex® xMAP® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.

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HCYTABM-17K
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Overview

Replacement Information
Description
Catalogue NumberHCYTABM-17K
Trade Name
  • MILLIPLEX
DescriptionMILLIPLEX® Human Cytokine Autoantibody IgM Kit
OverviewThe MILLIPLEX® Human Cytokine Autoantibody IgM Magnetic Bead Panel is a 23-plex kit to be used for the simultaneous detection of any or all of the following analytes in serum and plasma samples: Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω.
Background InformationAnti-cytokine antibodies occur frequently and are present in healthy individuals and in individuals with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren’s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.
References
Product Information
Detection methodLuminex xMAP
ConfigurationDesign your multiplex kit by choosing available analytes within this panel.
Precision, %
  • Intra-Assay: <15%
  • Inter-assay: <20%
Panel TypeMAGNETIC Immune Response
Quality LevelMQ200
Applications
ApplicationThe MILLIPLEX® Human Cytokine Autoantibody IgM Panel is a bead-based qualitative assay based on the Luminex® xMAP® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.
Key Applications
  • Multiplexing
Application Notes• This is a qualitative assay and yields results in Median Fluorescence Intensity (MFI).
• Four assay control beads are included in the base kit.
• This is an overnight assay.
• This assay requires 25 µL of 1:100 diluted plasma or serum.
Biological Information
Species Reactivity
  • Human
Analytes Available
  • BAFF/Blys
  • G-CSF
  • IFNβ
  • IFNγ
  • IL-1α
  • IL-6
  • IL-8
  • IL-10
  • IL-12 (p40)
  • IL-15
  • IL-17A
  • IL-17F
  • IL-18
  • IL-22
  • TNFα
  • IFNα2
  • GM-CSF
  • IL-2
  • IL-3
  • IL-4
  • Osteopontin
  • Platelet Factor-4
  • IFN-γ
Assay PanelEverything you need in a single kit.
Cross ReactivityThere was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size96-well plate
Material Package96 well plate
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
HCYTABM-17K 04065268088982

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