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526524 PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

526524
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₃H₁₃NO₃S 587852-28-6

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      塑膠安瓿;塑膠針藥瓶 5 mg
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      Description
      OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
      Catalogue Number526524
      Brand Family Calbiochem®
      SynonymsSMI-16a, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione
      References
      ReferencesXia, Z., et al. 2009. J. Med. Chem. 52, 74.
      Product Information
      CAS number587852-28-6
      FormYellow solid
      Hill FormulaC₁₃H₁₃NO₃S
      Chemical formulaC₁₃H₁₃NO₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      526524

      References

      Reference overview
      Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      SynonymsSMI-16a, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione
      DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number587852-28-6
      Chemical formulaC₁₃H₁₃NO₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesXia, Z., et al. 2009. J. Med. Chem. 52, 74.