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539690 Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem

539690
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₈Br₄O₅

Pricing & Availability

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539690-25MGCN
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      塑膠安瓿;塑膠針藥瓶 25 mg
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      Description
      OverviewA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
      Catalogue Number539690
      Brand Family Calbiochem®
      Synonyms3,4,5,6-Tetrabromofluorescein
      References
      ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
      Product Information
      ATP CompetitiveN
      FormLight brown solid
      Hill FormulaC₂₀H₈Br₄O₅
      Chemical formulaC₂₀H₈Br₄O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman arginine methyl transferase
      Primary Target IC<sub>50</sub>1.41 µM against human arginine methyl transferase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem Certificates of Analysis

      TitleLot Number
      539690

      References

      Reference overview
      Novac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-September-2007 JSW
      Synonyms3,4,5,6-Tetrabromofluorescein
      DescriptionA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
      FormLight brown solid
      Chemical formulaC₂₀H₈Br₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.