555550 Sigma-AldrichRho Kinase Inhibitor - Calbiochem
The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM).
More>> The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM). Less<<Rho Kinase Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P)
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 871543-07-6 | C₁₆H₂₁N₃O₂S • 2HCl |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 555550-1MGCN | 塑膠安瓿;塑膠針藥瓶 | 1 mg | |
| 555550-5MGCN | 玻璃瓶 | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available. |
| Catalogue Number | 555550 |
| Brand Family | Calbiochem® |
| Synonyms | H-1152, H-1152P, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl, ROCK Inhibitor, Dimethylfasudil (diMF, H-1152P) |
| References | |
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| References | Wen, Qiang, et al. 2012. Cell 150, 575. Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225. |
| Product Information | |
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| CAS number | 871543-07-6 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₁₆H₂₁N₃O₂S • 2HCl |
| Chemical formula | C₁₆H₂₁N₃O₂S • 2HCl |
| HS Code | 2935 90 99 |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | The Rho kinase inhibitor, CAS 871543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (Ki = 1.6 nM). |
| Biological Information | |
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| Primary Target | ROCK |
| Primary Target K<sub>i</sub> | 1.6 nM against G-protein Rho-associated kinase |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 555550-1MGCN | 04055977268393 |
| 555550-5MGCN | 04055977268409 |
Documentation
Rho Kinase Inhibitor - Calbiochem MSDS
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Rho Kinase Inhibitor - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 555550 |
References
| Reference overview |
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| Wen, Qiang, et al. 2012. Cell 150, 575. Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225. |
Brochure
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| Bulk Product Guide |