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426102 clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem

clasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Omuralide, Proteasome Inhibitor IX

Primary Target: 20S proteasome
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154226-60-5C₁₀H₁₅NO₄

Products

Catalogue NumberPackaging Qty/Pack
426102-100UGCN 塑膠安瓿;塑膠針藥瓶 100 μg
Description
OverviewA highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome.
Catalogue Number426102
Brand Family Calbiochem®
SynonymsOmuralide, Proteasome Inhibitor IX
References
ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
Fenteany, G., et al. 1995. Science 268, 726.
Product Information
CAS number154226-60-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₅NO₄
Chemical formulaC₁₀H₁₅NO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Applicationclasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.
Biological Information
Primary Target20S proteasome
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
426102-100UGCN 04055977187366

Documentation

clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem Certificates of Analysis

TitleLot Number
426102

References

Reference overview
Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
Fenteany, G., et al. 1995. Science 268, 726.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin

Citations

Title
  • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-February-2008 JSW
    SynonymsOmuralide, Proteasome Inhibitor IX
    DescriptionA cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed that in vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor for clasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50 approximately 1 µM). clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystin in vitro.
    FormWhite solid
    CAS number154226-60-5
    Chemical formulaC₁₀H₁₅NO₄
    Structure formulaStructure formula
    SolubilityDMSO (3 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
    Toxicity Standard Handling
    ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
    Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
    Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
    Fenteany, G., et al. 1995. Science 268, 726.
    Citation
  • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
    		•