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Merck

CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Sinónimos:
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Especie:
Human CDKN2B (1030), Mouse Cdkn2b (12579), Rat Cdkn2b (25164), Horse CDKN2B (100034122), dog CDKN2B (481563), chicken CDKN2B (395076), domestic guinea pig Cdkn2b (100732246), sheep CDKN2B (101107164), cow CDKN2B (527124), domestic cat CDKN2B (101087014)
ID UniProtKB:
P42772, O15125, Q6FI09
ID del gen:
  • Human(1030) Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(12579) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • Rat(25164) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • Horse(100034122) cyclin-dependent kinase 2B inhibitor
  • dog(481563) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • chicken(395076) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • domestic guinea pig(100732246) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • sheep(101107164) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • cow(527124) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • domestic cat(101087014) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
SAB4500078
Anti-p15 INK antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot
HPA063327
Anti-CDKN2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
MABS1950
Anti-p15 Antibody, clone PAT56B, clone PAT56B, from rat,
Reactividad de especies
mouse
Aplicación
immunohistochemistry
western blot
HPA073143
Anti-Cdkn2B Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
MABE1664
Anti-INK4b (p15) Antibody, clone GF10 (10C7A6), culture supernatant, clone GF10 (10C7A6), from mouse,
Reactividad de especies
human
Aplicación
western blot

Small Molecule - Inhibitor

Product Number
Descripción
Especie
R7772
Roscovitine, ≥98% (TLC),
Especie
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Especie
human, rat

Kits

Product Number
Descripción
Especie
S7802
CpG WIZ™ p15 -Methylation specific PCR assay, The CpG WIZ p15 Amplification Kit is used for determining the methylation status of the p15 promoter by methylation-specific PCR (MSP).,
Especie
human

esiRNA

Product Number
Descripción
Especie
EHU134441
MISSION® esiRNA, targeting human CDKN2B,
Especie
human