DMTF1
cyclin D binding myb-like transcription factor 1
Sinónimos:
DMP1, DMTF, hDMP1
Especie:
Human DMTF1 (9988), Mouse Dmtf1 (23857), Rat Dmtf1 (114485), naked mole-rat Dmtf1 (101715156), sheep DMTF1 (101111877), chicken DMTF1 (418646), cow DMTF1 (539676), Horse DMTF1 (100049982), domestic cat DMTF1 (101096302), dog DMTF1 (475217) ...Más
ID UniProtKB:
ID del gen:
- Human(9988) Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- Mouse(23857) cyclin D binding myb-like transcription factor 1
- Rat(114485) cyclin D binding myb-like transcription factor 1
- naked mole-rat(101715156) cyclin D binding myb-like transcription factor 1
- sheep(101111877) cyclin D binding myb-like transcription factor 1
- chicken(418646) cyclin D binding myb-like transcription factor 1
- cow(539676) cyclin D binding myb-like transcription factor 1
- Horse(100049982) cyclin D binding myb-like transcription factor 1
- domestic cat(101096302) cyclin D binding myb-like transcription factor 1
- dog(475217) cyclin D binding myb-like transcription factor 1
- domestic guinea pig(100732106) cyclin D binding myb-like transcription factor 1
- Domestic Rabbit(100356192) cyclin D binding myb-like transcription factor 1
- Zebrafish(436938) cyclin D binding myb-like transcription factor 1
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Antibodies
Product Number
Descripción
Reactividad de especies
Aplicación
Anti-DMTF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-DMTF1, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicación
western blot