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Merck

FBXW7

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Sinónimos:
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Especie:
ID UniProtKB:
ID del gen:
  • Human(55294) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
  • Mouse(50754) F-box and WD-40 domain protein 7
  • Rat(100360914) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • domestic guinea pig(100734383) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • naked mole-rat(101717987) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • Zebrafish(564991) F-box and WD repeat domain containing 7
  • sheep(101104688) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • dog(475465) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • Horse(100062294) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • domestic cat(101096146) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
  • cow(540932) F-box and WD repeat domain containing 7
  • chicken(422481) F-box and WD repeat domain containing 7

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-FBXW7 antibody produced in mouse, clone 3D1, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry

western blot
Anti-Cdc4 (FBXW7) Antibody, clone 9D8.1, clone 9D8.1, from mouse,
Reactividad de especies
human, mouse
Aplicación
western blot
Anti-FBXW7 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP237, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
flow cytometry
immunohistochemistry
Anti-F-box/WD repeat-containing protein 7 Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
bovine, canine, feline, gorilla, horse, human, porcine, rhesus macaque
Aplicación
immunohistochemistry
western blot
Anti-Cdc4 Antibody, Chemicon®, from rabbit,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Descripción
Especie
MISSION® esiRNA, targeting human FBXW7,
Especie
human
MISSION® esiRNA, targeting mouse Fbxw7,
Especie
mouse