MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Sinónimos:
CMM5, MSH-R, SHEP2
Especie:
Human MC1R (4157), Mouse Mc1r (17199), Rat Mc1r (292083), domestic cat MC1R (493917), dog MC1R (489652), Horse MC1R (100136907), cow MC1R (281298), Goat MC1R (100750239), Domestic Rabbit MC1R (100340038), sheep MC1R (102099064) ...Más
ID UniProtKB:
ID del gen:
- Human(4157) Summary: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
- Mouse(17199) melanocortin 1 receptor
- Rat(292083) melanocortin 1 receptor
- domestic cat(493917) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- dog(489652) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Horse(100136907) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- cow(281298) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Goat(100750239) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Domestic Rabbit(100340038) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- sheep(102099064) melanocortin 1 receptor
- naked mole-rat(101726602) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- chicken(427562) melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Zebrafish(353151) melanocortin 1 receptor
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Antibodies
Product Number
Descripción
Reactividad de especies
Aplicación
Anti- MC1 Receptor antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Anti-MC1R (C-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot
Anti-Melanocortin Receptor-1 Antibody, Chemicon®, from rabbit,
Reactividad de especies
mouse
Aplicación
ELISA
western blot
western blot