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Merck

407286

Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6)

liquid, clone 272-17E6, Calbiochem®

Sinónimos:

Anti-CD51

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203

Nombre del producto

Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6), liquid, clone 272-17E6, Calbiochem®

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

272-17E6, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

dilution

(Cell Inhibition Assays
ELISA
Flow Cytometry (2.5 µg/mL)
Immunoprecipitation (2.5 µg/mL))

isotype

IgG1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGAV(3685)

Application

Cell Inhibition Assays (see application reference)

ELISA (see application reference)

Flow Cytometry (2.5 µg/ml, see application reference)

Immunoprecipitation (2.5 µg/ml, see application reference)

Disclaimer

Toxicity: Standard Handling (A)

General description

Purified mouse monoclonal antibody. Recognizes the αv integrin chain and all αv-containing integrins.
Recognizes the αv integrin chain and all αv-containing integrins.
This Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) is validated for use in Cell Inhibition Assays, ELISA, FC, IP for the detection of Integrin αv (Ab-1).

Immunogen

Human
human placental αvβ₃ integrin

Other Notes

Akiyama, S.K. 1996. Hum. Cell9, 181.
Hynes, R.O. 1992. Cell69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J.4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol.3, 179.
Hynes, R.O. 1987. Cell45, 549.
Cross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In PBS, pH 7.6.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Journal of biomolecular screening, 17(6), 835-842 (2012-04-05)
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Colin D H Ratcliffe et al.
Traffic (Copenhagen, Denmark), 17(6), 670-688 (2016-03-05)
The integrin family of cell adhesion receptors link extracellular matrices to intracellular signaling pathways and the actin cytoskeleton; and regulate cell migration, proliferation and survival in normal and diseased tissues. The subcellular location of integrin receptors is critical for their
Abdullah Karadag et al.
Cancer research, 65(24), 11545-11552 (2005-12-17)
The up-regulation of various matrix metalloproteinases (MMP), certain cell receptors such as integrins and CD44, and the SIBLING family of integrin-binding glycophosphoproteins have been reported separately and in various combinations for many types of tumors. The mechanisms by which these

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