SAB4503685
Anti-CEP135 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Centrosomal protein 4, Centrosomal protein of 135 kDa, Cep135
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
9
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 133 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CP135(9662)
General description
Anti-CEP135 Antibody detects endogenous levels of total CEP135 protein.
Cep135 (centrosomal protein 135) is a cartwheel protein. It has a coiled-coil domain and conserved regions near the N-terminus and the C-terminus, respectively. It is mapped to human chromosome 4q12.
Immunogen
The antiserum was produced against synthesized peptide derived from human CEP135.
Immunogen Range: 1081-1130
Immunogen Range: 1081-1130
Application
Anti-CEP135, C-Terminal antibody has been used in immunofluorescence staining.
Biochem/physiol Actions
Mutation in Cep135 (centrosomal protein 135) result in primary microcephaly. It induces centriole assembly and stability. CEP135 helps to maintain the structure and organization of microtubules. This protein plays a major role in centriole biogenesis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function
Hussain MS, et al.
American Journal of Human Genetics, 90(5), 871-878 (2012)
Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7
Noordstra I, et al.
Journal of Cell Science, 129(22), 4278-4288 (2016)
A Short CEP135 Splice Isoform Controls Centriole Duplication
Dahl KD, et al.
Current Biology, 25(19), 2591-2596 (2015)