F3393

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

Name: Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit
Brand: SIGMA

fractionated antiserum, lyophilized powder

Sinónimos:

Anti-FGF2, Anti-bFGF

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01322020

Nombre del producto

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit, fractionated antiserum, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, bovine, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1:1,000

impurities

endotoxin, tested

UniProt accession no.

P09038

application(s)

research pathology

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

bovine ... FGF2(281161)
human ... FGF2(2247)
rat ... Fgf2(54250)

Analysis Note

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Application

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:

immunohistochemistry
immunostaining
immunoblotting

Biochem/physiol Actions

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Immunogen

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Lot/Batch Number

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Serotonergic neurons transiently require a midline-derived FGF signal.

B G Condron

Neuron, 24(3), 531-540 (1999-12-14)

In the grasshopper CNS, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or SERT. To test if the midline contains an activity that induces SERT, cuts were made that separated serotonergic cell

Effect of human umbilical cord blood mesenchymal stem cells administered by intravenous or intravitreal routes on cryo-induced retinal injury

Mohamed EM, et al.

IUBMB Life, 69(3), 188-201 (2017)

Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms

Erdem H, et al.

Nigerian Journal of Clinical Practice, 18(5), 638-643 (2015)

Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats.

Qian Liu et al.

Experimental and therapeutic medicine, 23(3), 216-216 (2022-02-08)

Hypertension is associated with bladder symptoms. The present study investigated whether an angiotensin receptor blocker could improve the symptoms and pathological changes associated with a neurogenic bladder (NB). A Sprague-Dawley rat model of NB was constructed. Rats in the sham

Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies.

Joost F M Lensen et al.

Journal of the American Society of Nephrology : JASN, 16(5), 1279-1288 (2005-03-25)

Glycosaminoglycans (GAG) play an important role in renal homeostasis. They are strongly negatively charged polysaccharides that bind and modulate a myriad of proteins, including growth factors, cytokines, and enzymes. With the aid of specific phage display-derived antibodies, the distribution of

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Data Sheet - F3393

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