- Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.
Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.
American journal of physiology. Lung cellular and molecular physiology (2017-07-08)
Insa Bultmann-Mellin, Katharina Dinger, Carolin Debuschewitz, Katharina M A Loewe, Yvonne Melcher, Miro T W Plum, Sarah Appel, Gunter Rappl, Sebastian Willenborg, Astrid C Schauss, Christian Jüngst, Marcus Krüger, Sven Dressler, Tomoyuki Nakamura, Frank Wempe, Miguel A Alejandre Alcázar, Anja Sterner-Kock
PMID28684544
RESUMEN
Deficiency of the extracellular matrix protein latent transforming growth factor-β (TGF-β)-binding protein-4 (LTBP4) results in lack of intact elastic fibers, which leads to disturbed pulmonary development and lack of normal alveolarization in humans and mice. Formation of alveoli and alveolar septation in pulmonary development requires the concerted interaction of extracellular matrix proteins, growth factors such as TGF-β, fibroblasts, and myofibroblasts to promote elastogenesis as well as vascular formation in the alveolar septae. To investigate the role of LTBP4 in this context, lungs of LTBP4-deficient (
MATERIALES
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Marca
Descripción del producto
Sigma-Aldrich
Anticuerpo anti-actina, αmúsculo liso monoclonal de ratón, clone 1A4, purified from hybridoma cell culture
Sigma-Aldrich
Anti-von Willebrand Factor antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution