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  • Assessment of androgen receptor agonistic/antagonistic effects on 25 chemicals in household applicants by OECD in vitro stably transfected transcriptional activation assays.

Assessment of androgen receptor agonistic/antagonistic effects on 25 chemicals in household applicants by OECD in vitro stably transfected transcriptional activation assays.

Chemosphere (2017-10-27)
Hee-Seok Lee, Eun-Jung Park, Songyi Han, Gyeong-Yong Oh, Hui-Seung Kang, Jin-Hyang Suh, Min-Ki Shin, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Young-Ho Koh, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
RESUMEN

The aim of this study is to assess the androgen receptor (AR) agonistic/antagonistic effects on various chemicals, which are used in household products including cleaning agents and wetted tissues by in vitro OECD test guideline No. 458 (using AR-EcoScreen™ cell line) and the me-too test method (using 22Rv1cell line), which was adopted as OECD project No. 4.99. All chemicals were not determined as AR agonists. However α-dodecyl-ω-hydroxypoly (oxyethylene) and 3-iodo-2-propynyl butylcarbamate have shown a weak AR antagonistic effects with IC

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Sigma-Aldrich
Hydroxyflutamide, ≥98% (HPLC)