- Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome.
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome.
Frontiers in immunology (2017-01-18)
Zheng Xu-Yang, Bian Pei-Yu, Ye Chuan-Tao, Ye Wei, Ma Hong-Wei, Tang Kang, Zhang Chun-Mei, Lei Ying-Feng, Wei Xin, Wang Ping-Zhong, Huang Chang-Xing, Bai Xue-Fan, Zhang Ying, Jia Zhan-Sheng
PMID28096800
RESUMEN
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated with the disease severity and HTNV load in the plasma of HFRS patients.
MATERIALES