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CBL511 | Anti-CD55 Antibody, clone BRIC 216

CBL511
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IP, WB, IHC, IH(P), FUNC M Purified Monoclonal Antibody
      Description
      Catalogue NumberCBL511
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD55 Antibody, clone BRIC 216
      Alternate Names
      • DAF
      References
      Product Information
      FormatPurified
      PresentationThe immunoglobulin was purified from cell culture supernatant by affinity chromatography using protein G and is presented in 1 M Tris-buffered saline, pH 7.5, containing no preservatives. The antibody has been sterile-filtered.
      Applications
      ApplicationAnti-CD55 Antibody, clone BRIC 216 is an antibody against CD55 for use in FC, IP, WB, IH, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Affects Function
      Application NotesWestern blot: Non-reduced erythrocyte membrane prep; antigen is sialidase and trypsin resistant, pronase, chymotrypsin and AET sensitive
      Flow Cytometry
      Immunohistochemistry: Frozen and formalin-fixed paraffin-embedded sections. Protease antigen retreival is recommended.
      Immunoprecipitation
      Inhibition studies


      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman fibroblast cell line
      CloneBRIC 216
      HostMouse
      SpecificityThis antibody recognizes the CD55 antigen a 70 kDa glycoprotein also known as Decay Accelerating Factor (DAF). The antigen is present on erthrocytes and other circulating blood cells and also on cells in non-haemopoietic tissue particularly epithelium and endothelium. It is found specifically at the placental fetal-maternal interface.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.
      Gene Symbol
      • CD55
      • CR
      • TC
      • DAF
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08174 # Also acts as the receptor for echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33).
      SIZE: 381 amino acids; 41400 Da
      SUBUNIT: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
      SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
      TISSUE SPECIFICITY: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
      DOMAIN: SwissProt: P08174 The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
      PTM: The Ser/Thr-rich domain is heavily O-glycosylated.
      SIMILARITY: Belongs to the receptors of complement activation (RCA) family. & Contains 4 Sushi (CCP/SCR) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsAliquot antibody into small volumes and store at -20°C for up to 12 months from the date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      MOUSE ANTI-HUMAN CD55 MONOCLONAL ANTIBODY - 2112518 2112518
      MOUSE ANTI-HUMAN CD55 MONOCLONAL ANTIBODY - 2424675 2424675
      MOUSE ANTI-HUMAN CD55 - 2559660 2559660
      MOUSE ANTI-HUMAN CD55 -2601704 2601704
      MOUSE ANTI-HUMAN CD55 -2642180 2642180
      MOUSE ANTI-HUMAN CD55 -2709153 2709153
      MOUSE ANTI-HUMAN CD55 -2736655 2736655
      MOUSE ANTI-HUMAN CD55 -2746518 2746518
      MOUSE ANTI-HUMAN CD55 -2764018 2764018
      MOUSE ANTI-HUMAN CD55 -2788900 2788900
      MOUSE ANTI-HUMAN CD55 MONOCLONAL ANTIBODY - 2274256 2274256
      MOUSE ANTI-HUMAN CD55 MONOCLONAL ANTIBODY - 2361780 2361780
      MOUSE ANTI-HUMAN CD55 MONOCLONAL ANTIBODY -2496158 2496158

      Referências

      Visão geral das referênciasPub Med ID
      Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor.
      Coyne, K E, et al.
      J. Immunol., 149: 2906-13 (1992) 1992

      Mostrar Resumo
      1383332 1383332
      Preferential expression of the complement regulatory protein decay accelerating factor at the fetomaternal interface during human pregnancy.
      Holmes, C H, et al.
      J. Immunol., 144: 3099-105 (1990) 1990

      Mostrar Resumo
      1691227 1691227

      Ficha de dados

      Título
      MOUSE ANTI-HUMAN CD55

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