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07-544 | Anti-phospho-nNOS/NOS I (Ser1417) Antibody

07-544
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-544
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-nNOS/NOS I (Ser1417) Antibody
      OverviewNote: ADMA (Catalog #19-169) and NMMA (Catalog #19-170) are inhibitors of NOS
      References
      Product Information
      FormatAffinity Purified
      Applications
      ApplicationAnti-phospho-nNOS/NOS I (Ser1417) Antibody is an antibody against phospho-nNOS/NOS I (Ser1417) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acids surrounding Ser1417 of human neuronal Nitric Oxide Synthase (nNOS).
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NotePredicted to cross-react with mouse, zebrafish and frog based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NOS1
      • bNOS
      • nNOS
      • N-NOS
      • IHPS1
      • NC-NOS
      • NOS
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
      COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
      SIZE: 1434 amino acids; 160970 Da
      SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).
      SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
      DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).
      DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.
      SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain.
      Molecular WeightMr 170kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Anti-phospho-nNOS/NOS I (Ser1417) 2475674
      Anti-phospho-nNOS/NOS I (Ser1417) 2842901
      Anti-phospho-nNOS/NOS I (Ser1417) - 26782 26782
      Anti-phospho-nNOS/NOS I (Ser1417) - DAM1437152 DAM1437152
      Anti-phospho-nNOS/NOS I (Ser1417) -2517881 2517881

      Referências

      Visão geral das referênciasAplicaçãoPub Med ID
      (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle.
      Nogueira, L; Ramirez-Sanchez, I; Perkins, GA; Murphy, A; Taub, PR; Ceballos, G; Villarreal, FJ; Hogan, MC; Malek, MH
      The Journal of physiology 589 4615-31 2011

      Mostrar Resumo
      21788351 21788351
      Modulation of the dystrophin-associated protein complex in response to resistance training in young and older men.
      Kosek, DJ; Bamman, MM
      Journal of applied physiology (Bethesda, Md. : 1985) 104 1476-84 2008

      Mostrar Resumo
      Western Blotting18356484 18356484
      AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
      Chen, Z P, et al.
      Am. J. Physiol. Endocrinol. Metab., 279: E1202-6 (2000) 2000

      Mostrar Resumo
      11052978 11052978

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      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies