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05-691


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  • More Than Sure

    Tipo de documento:
    Folleto
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • COA 105691

    Tipo de documento:
    Certificado de análisis
    Referencia del producto:
    105691

  • Smart Up your lab

    Tipo de documento:
    Folleto
    Referencia del producto:
    Múltiplo
    Nombre del producto:
    Múltiplo

  • p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex. 12101238

    Modulation of the interaction between U1 snRNP and the 5' splice site (5'ss) is a key event that governs 5'ss recognition and spliceosome assembly. Using the methylene blue-mediated cross-linking method (Z. R. Liu, A. M. Wilkie, M. J. Clemens, and C. W. Smith, RNA 2:611-621, 1996), a 65-kDa protein (p65) was shown to interact with the U1-5'ss duplex during spliceosome assembly (Z. R. Liu, B. Sargueil, and C. W. Smith, Mol. Cell. Biol. 18:6910-6920, 1998). In this report, p65 was identified as p68 RNA helicase and shown to be essential for in vitro pre-mRNA splicing. Depletion of endogenous p68 RNA helicase does not affect the loading of the U1 snRNP to the 5'ss during early stage of splicing. However, dissociation of the U1 from the 5'ss is largely inhibited. The data suggest that p68 RNA helicase functions in destabilizing the U1-5'ss interactions. Furthermore, depletion of p68 RNA helicase arrested spliceosome assembly at the prespliceosome stage, suggesting that p68 may play a role in the transition from prespliceosome to spliceosome.
    Tipo de documento:
    Referencia
    Referencia del producto:
    05-850
    Nombre del producto:
    Anti-p68 Antibody, clone204
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