Millipore Sigma Vibrant Logo

115500 Adenophostin A, Hexasodium Salt - Calbiochem

Adenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.

Adenophostin A, Hexasodium Salt - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Primary Target: Type 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
View Products on Sigmaaldrich.com
115500
Ver preços e disponibilidade

Panorama geral

Replacement Information

Tabela com principais espec.

Empirical Formula
C₁₆H₂₀N₅O₁₈P₃ · 6Na

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
115500-50UG
Verificando a disponibilidade...
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      		 50 μg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      —
      Solicitar preço
      		 —
      Description
      OverviewOne of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
      Catalogue Number115500
      Brand Family Calbiochem®
      References
      ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      HS Code2934 99 99
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAdenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.
      Biological Information
      Primary TargetType 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
      Primary Target IC<sub>50</sub>EC50 = 10.9 nM against InsP3R
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      115500-50UG 07790788060244

      Documentation

      Adenophostin A, Hexasodium Salt - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Adenophostin A, Hexasodium Salt - Calbiochem Certificados de análise

      TítuloNúmero do lote
      115500

      Referências

      Visão geral de referência
      Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

      Brochura

      Título
      Inorganics & Solvents for classical analysis
      Safety Connects - Solvents Withdrawal System Brochure
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      DescriptionA glyconucleotide originally isolated from the culture broth of Penicillium brevicompactum. Adenophostin A is the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R). Exhibits about 50-100 fold greater affinity for the InsP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R. Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to degradation by the enzymes that metabolize (1,4,5)InsP3.
      FormWhite solid
      Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
      Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
      DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
      Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
      Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
      Hirota, J., et al. 1995. FEBS Lett. 368, 248.
      Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

      Produtos e aplicações relacionadas

      Accessories (Primary)

      Número de catálogo Descrição  
      106710 Sistema de transvase para tambores e barris em aço inoxidável Preço e disponibilidade

      Accessories (Secondary)

      Número de catálogo Descrição  
      108801 Chave para garrafas Preço e disponibilidade

      Categorias

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators