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MABS502 Anti-CYP11B1 Antibody, clone 80-7

Anti-CYP11B1 Antibody, clone 80-7 is an antibody against CYP11B1 for use in Western Blotting and Immunohistochemistry.

Anti-CYP11B1 Antibody, clone 80-7 : Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: CYP11B1, S11BH UniProt Number: P15538
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MABS502
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS502
      DescriptionAnti-CYP11B1 Antibody, clone 80-7
      Alternate Names
      • Cytochrome P450 11B1, mitochondrial
      • CYPXIB1
      • Cytochrome P-450c11
      • Cytochrome P450C11
      • Steroid 11-beta-hydroxylase
      • CYP11B1
      Background InformationCytochrome P450 11B1, mitochondrial (EC1.14.15.4, EC1.14.15.5; UniProt P15538; also known as CYPXIB1, Cytochrome P-450c11, Cytochrome P450C11, Cytochrome P450 subfamily XIB polypeptide 1, Cytochrome P450 XIB1, Steroid 11-beta-monooxygenase, Steroid 11-beta-hydroxylase) is encoded by the CYP11B1 (Also known as CPN1, CYP11B, FHI, P450C11, S11BH) gene in human (Gene ID 1584). CYP11B1 protein is a member of the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is localized to the inner mitochondrial membrane and mediates the conversion of progesterone to cortisol in the adrenal cortex. CYP11B1 gene mutations are known causes of adrenal hyperplasia 4 (AH4), a form of congenital adrenal hyperplasia due to defective synthesis of cortisol.
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationPurified rat monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CYP11B1 Antibody, clone 80-7 is an antibody against CYP11B1 for use in Western Blotting and Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected exogenously expressed human CYP11B1, but not CYP11B1 in 10 µg of HEK293 cell lysate.
      Western Blotting Analysis: A representative lot detected transfected CYP11B1 in HEK293 cells and endogenous CYP11B1 in mitochondrial preparation from human adrenocortical cell line HAC15 (Gomez-Sanchez, C.E., et al. 2014 Mol. Cell. Endocrinol. 383(1-2):111-117).
      Immunohistochemistry Analysis: A representative lot detected CYP11B1 in normal human adrenal tissue.
      Biological Information
      ImmunogenChicken serum albumin-conjugated linear peptide corresponding to human CYP11B1 near the N-terminus.
      EpitopeNear N-terminus
      Clone80-7
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CYP11B1
      • S11BH
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~52 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC12 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected CYP11B1 in 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      MABS502 04055977170702

      Documentation

      Anti-CYP11B1 Antibody, clone 80-7 MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Anti-CYP11B1 Antibody, clone 80-7 Certificados de análise

      TítuloNúmero do lote
      Anti-CYP11B1, clone 80-7 - 2986028 2986028
      Anti-CYP11B1, clone 80-7 - 3249540 3249540
      Anti-CYP11B1, clone 80-7 - 3445031 3445031
      Anti-CYP11B1, clone 80-7 - 3561545 3561545
      Anti-CYP11B1, clone 80-7 - 3610488 3610488
      Anti-CYP11B1, clone 80-7 - 3886653 3886653
      Anti-CYP11B1, clone 80-7 - 3910239 3910239
      Anti-CYP11B1, clone 80-7 - 3979868 3979868
      Anti-CYP11B1, clone 80-7 - 4020573 4020573
      Anti-CYP11B1, clone 80-7 - 4031368 4031368
      Show more

      Informações técnicas

      Título
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.