Millipore Sigma Vibrant Logo

AB1529 Anti-Nitric Oxide Synthase I Antibody

View Products on Sigmaaldrich.com
AB1529
100 µL  
Recuperando preço...
O preço não pôde ser recuperado
Quantidade mínima necessária para ser múltipla de
Maximum Quantity is
Após finalização do pedido Mais informações
Você salvou ()
 
Solicitar preço
Disponibilidade limitada
Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      Ofertas especiais

       

      Contatar o serviço de atendimento ao cliente

      Panorama geral

      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, R, RbWB, IHCShSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1529
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Nitric Oxide Synthase I Antibody
      Alternate Names
      • NOS I
      • bNOS
      • nNOS
      References
      Product Information
      FormatSerum
      HS Code3002 15 90
      PresentationSheep serum. Lyophilized, no preservatives. Reconstitute with 100 μL of sterile distilled water. Centrifuge to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationDetect Nitric Oxide Synthase I using this Anti-Nitric Oxide Synthase I Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:500-1,000

      Immunoblotting

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 21 amino acid peptide (1409-1429) of the neuronal form of NOS from rat cerebellum, coupled to KLH. The sequence is H-RSESIAFIEESKKDADEVFSS-NH2.
      HostSheep
      SpecificitybNOS (neuronal). Not yet tested for cross-reactivity to iNOS or eNOS. See reference below.
      Species Reactivity
      • Guinea Pig
      • Rat
      • Rabbit
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NOS1
      • nNOS
      • NC-NOS
      • N-NOS
      • IHPS1
      • bNOS
      • NOS
      • EC 1.14.13.39
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
      COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
      SIZE: 1434 amino acids; 160970 Da
      SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).
      SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
      DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).
      DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.
      SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20 to -70°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      AB1529 04053252512490

      Documentation

      Anti-Nitric Oxide Synthase I Antibody MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Anti-Nitric Oxide Synthase I Antibody Certificados de análise

      TítuloNúmero do lote
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) 3070791
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 3217095 3217095
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 3863404 3863404
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 3886036 3886036
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 3903313 3903313
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 3937840 3937840
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) - 4032022 4032022
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) -2659156 2659156
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) -2677847 2677847
      SHEEP ANTI- NITRIC OXIDE SYNTHASE (bNOS) -2728417 2728417

      Referências

      Visão geral das referênciasAplicaçãoEspéciesPub Med ID
      Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
      Seifi, M; Brown, JF; Mills, J; Bhandari, P; Belelli, D; Lambert, JJ; Rudolph, U; Swinny, JD
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  10361-78  2014

      Mostrar Resumo
      25080596 25080596
      Enteric neuropathy evoked by repeated cisplatin in the rat.
      G Vera,M Castillo,P A Cabezos,A Chiarlone,M I Martín,A Gori,G Pasquinelli,G Barbara,V Stanghellini,R Corinaldesi,R De Giorgio,R Abalo
      Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society  23  2011

      Mostrar Resumo
      21299719 21299719
      Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.
      Liu S, Ren W, Qu MH, Bishop GA, Wang GD, Wang XY, Xia Y, Wood JD
      Br J Pharmacol  159  222-36. Epub 2009 Nov 27.  2010

      Mostrar Resumo Texto completo do artigo
      20002096 20002096
      Localization of muscarinic receptors M1R, M2R and M3R in the human colon.
      A M Harrington,C J Peck,L Liu,E Burcher,J M Hutson,B R Southwell
      Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society  22  2010

      Mostrar Resumo
      20146726 20146726
      Inhibitory neuromuscular transmission to ileal longitudinal muscle predominates in neonatal guinea pigs.
      Patel BA, Dai X, Burda JE, Zhao H, Swain GM, Galligan JJ, Bian X
      Neurogastroenterol Motil  22  909-18, e236-7. Epub 2010 May 13.  2010

      Mostrar Resumo Texto completo do artigo
      20482699 20482699
      Postnatal downregulation of inhibitory neuromuscular transmission to the longitudinal muscle of the guinea pig ileum.
      Bian X, Burda JE, Carrasquillo M, Galligan JJ
      Neurogastroenterol Motil  21  969-77. Epub 2009 Apr 17.  2009

      Mostrar Resumo
      19374637 19374637
      Postnatal maturation of the gastrointestinal tract: a functional and immunohistochemical study in the guinea-pig ileum at weaning.
      Raquel Abalo,Gema Vera,Antonio José Rivera,Ernesto Moro-Rodríguez,María Isabel Martín-Fontelles
      Neuroscience letters  467  2009

      Mostrar Resumo
      19819299 19819299
      Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system.
      Liu, S; Qu, MH; Ren, W; Hu, HZ; Gao, N; Wang, GD; Wang, XY; Fei, G; Zuo, F; Xia, Y; Wood, JD
      The Journal of comparative neurology  511  847-62  2008

      Mostrar Resumo Texto completo do artigo
      Guinea Pig18925632 18925632
      High affinity choline transporter immunoreactivity in rat ileum myenteric nerves.
      Andrea M Harrington, J M Hutson, Bridget R Southwell
      Cell and tissue research  327  421-31  2007

      Mostrar Resumo
      17093920 17093920
      Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.
      Wierup, N; Gunnarsdóttir, A; Ekblad, E; Sundler, F
      BMC neuroscience  8  51  2007

      Mostrar Resumo Texto completo do artigo
      17625001 17625001

      Brochura

      Título
      Pathways and Biomarkers of Oxidative Stress

      Informações técnicas

      Título
      White Paper- Modern Methods in Oxidative Stress Research

      Produtos e aplicações relacionadas

      Related Products

      Número de catálogo Descrição  
      07-544 Anti-phospho-nNOS/NOS I (Ser1417) Antibody Preço e disponibilidade
      AB5380 Anti-Nitric Oxide Synthase I Antibody Preço e disponibilidade

      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies