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215921 Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl

Primary Target: Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
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215921
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CAS #Empirical Formula
69-09-0C₁₇H₁₉ClN₂S · HCl

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      Description
      OverviewInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
      Catalogue Number215921
      Brand Family Calbiochem®
      Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
      References
      ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
      Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
      Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
      Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
      Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
      Vadas, P., et al. 1986. Agents Actions 19, 194.
      Marshak, P.R., et al. 1985. Biochemistry 24, 144.
      Product Information
      CAS number69-09-0
      ATP CompetitiveN
      FormOff-white crystalline solid
      Hill FormulaC₁₇H₁₉ClN₂S · HCl
      Chemical formulaC₁₇H₁₉ClN₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
      Primary Target IC<sub>50</sub>17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSO1750000
      Safety Information
      R PhraseR: 25-26-36/37/38

      Toxic if swallowed.
      Very toxic by inhalation.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      215921-500MG 07790788048549

      Documentation

      Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      215921

      Referências

      Visão geral de referência
      Lee, M.S., et al. 2007. Cancer Res. 67, 11359.
      Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
      Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
      Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
      Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
      Vadas, P., et al. 1986. Agents Actions 19, 194.
      Marshak, P.R., et al. 1985. Biochemistry 24, 144.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-April-2018 JSW
      Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
      DescriptionInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
      FormOff-white crystalline solid
      CAS number69-09-0
      RTECSSO1750000
      Chemical formulaC₁₇H₁₉ClN₂S · HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
      SolubilityH₂O (50 mg/ml) or Methanol (10 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
      Toxicity Toxic
      Merck USA index14, 2185
      ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
      Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
      Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
      Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
      Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
      Vadas, P., et al. 1986. Agents Actions 19, 194.
      Marshak, P.R., et al. 1985. Biochemistry 24, 144.

      Produtos e aplicações relacionadas

      Categorias

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors