Millipore Sigma Vibrant Logo

239763 Cycloheximide - CAS 66-81-9 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 239763m) on sigmaaldrich.com.

Cycloheximide - CAS 66-81-9 - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Primary Target: hFKBP12
View Products on Sigmaaldrich.com
239763
  
Recuperando preço...
O preço não pôde ser recuperado
Quantidade mínima necessária para ser múltipla de
Maximum Quantity is
Após finalização do pedido Mais informações
Você salvou ()
 
—
Solicitar preço
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

       

      Contatar o serviço de atendimento ao cliente

      Panorama geral

      Replacement Information

      Tabela com principais espec.

      CAS #Empirical Formula
      66-81-9C₁₅H₂₃NO₄
      Description
      OverviewAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.
      Catalogue Number239763
      Brand Family Calbiochem®
      References
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
      Product Information
      CAS number66-81-9
      FormOff-white solid
      Hill FormulaC₁₅H₂₃NO₄
      Chemical formulaC₁₅H₂₃NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargethFKBP12
      Primary Target K<sub>i</sub>3.4 µM
      Purity≥90% by assay
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMA4375000
      Safety Information
      R PhraseR: 28-40-51/53-61

      Very toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
      May cause harm to the unborn child.
      S PhraseS: 45-53-61

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      239763 0

      Documentation

      Cycloheximide - CAS 66-81-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Cycloheximide - CAS 66-81-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      239763

      Referências

      Visão geral de referência
      Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

      Brochura

      Título
      Bulk Product Guide

      Citações

      Título
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
      		•
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-March-2019 JSW
      DescriptionAn antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, however it inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
      FormOff-white solid
      CAS number66-81-9
      RTECSMA4375000
      Chemical formulaC₁₅H₂₃NO₄
      Structure formulaStructure formula
      Purity≥90% by assay
      SolubilityChloroform, Ethanol, Methanol, or H₂O (10 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2728
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
      Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
      Citation
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
      		•