OptiScale® Capsule Filters for Aseptic Processing Applications
OptiScale® capsules, with a large variety of filtration media options, are a family of convenient, disposable filters ideal for media selection, process screening and scaling.
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OptiScale® capsules, with a large variety of filtration media options, are a family of convenient, disposable filters ideal for media selection, process screening and scaling. Menos
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FAQ
| Pergunta | Resposta |
|---|---|
| What is the compatibility of Durapore with high pH solutions? | The upper recommended pH limit for Durapore membranes is 10. At pH >10, the hydrophilization layer of the membrane may become subject to hydrolysis. The extent of hydrolysis is a function of time, temperature , concentration and time of exposure. Upon exposure to high pH, the hydrophylization layer can swell which could result in a loss of permeability or flux. The hydrolysis of the hydrophilic layer will also lead to increased extractables from the membrane. |
| What are Millipore's general recommendations for filtering high pH solutions? | For applications involving pH > 10, Millipore recommends the use or our PES membranes Express SHF or Express SHC. For information on these filters : Express SHF: http://www.millipore.com/catalogue.nsf/docs/C8873 Express SHC: http://www.millipore.com/catalogue.nsf/docs/C9146 |
| How can I differentiate filter plugging due to air bubbles, particulates, surface tension, inappropriate filter size, etc.? | Air locking will occur when filtration is initiated without adequate venting or when air bubbles become trapped in fluid lines. Air will pass easily through a dry hydrophillic or hydrophobic filter. However, when a filter is wet and air is applied to a surface, the air will remain until it is manually moved upstream by venting or until the bubble point of the filter is reached. Bubble point is defined as the pressure at which gas displaces liquid for the largest set of filter pores and is able to flow through the pores. Air locking reduces the effective filtration area of the filter and thus reduces the flow rate. Surface tension refers to the strong cohesive forces present between molecules at the surface of a liquid. The higher the surface tension, the more force is required to force fluid through the membrane.. Innapropriate filter size will can cause a filter to plug prematurely. Filter pore size is chosen based on the application. If the application requires a sterile fluid, than a 0.22 micron membrane would be used for standard solutions that have bacterial bioburden. A 0.1 micron filter would be used for applications where mycoplasma is a concern. Where virus contamination is a concern, ultrafiltration would be required. The selection of a filter pore size that is smaller than that required for the application will cause a decrease in filter capacity and an increase in cost. |
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Multimedia Durapore® Capsule FiltersProviding sterility assurance, high flow rates and extended throughputs, low extractables, and broad chemical compatibility.Saiba mais >> |
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Produtos relacionados por: Application Facete
| Antibody Purification |
| Dialysis and Filtration |
Produtos relacionados por: Brand Facete
| Optiscale™ |
Categorias
| Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Durapore |
Description
OptiScale® disposable capsule filters provide a convenient small-volume option for process screening and scaling. These “drop in” filters are ideal for evaluating biopharmaceuticals. OptiScale® capsule filters offer speed-to-market strategies for efficiently developing compounds and biotherapeutics.
The OptiScale® capsule is ideally suited for process development and screening. OptiScale® capsules are faster and easier to set-up than conventional 47-mm discs, and completely disposable.
Typical Applications
OptiScale® capsules are ideal for filtration of
- cell culture media
- media additives
- small and large volume parenterals
- bacterial cell processing
- buffer preparations
- ophthalmic solutions
- plasma proteins, serum
- vaccines
- pharmaceutical facility water
- process intermediates
| OptiScale Durapore | OptiScale Multilayer Durapore | OptiScale Durapore Multimedia | OptiScale Millipore Express SHF | OptiScale Millipore Express SHC | OptiScale Millipore Express SHR | Optiscale® Millipore Express® PHF | |
| Materials of Construction | |||||||
| Filter | Polyvinylidene Fluoride (PVDF) | Polyvinylidene Fluoride (PVDF) | Mixed Cellulose Esters (MCE) Polyvinylidene Fluoride (PVDF) |
Polyethersulfone (PES) | Polyethersulfone (PES) | Polyethersulfone (PES) | Polyethersulfone (PES) |
| Prefilter | Mixed Cellulose Esters (MCE) | ||||||
| Filter Support | Polypropylene | Polypropylene | Polypropylene | Polypropylene | Polypropylene | Polypropylene | Polypropylene |
| Housing and Drainage Disk | Polycarbonate | Polycarbonate | Polycarbonate | Polycarbonate | Polycarbonate | Polycarbonate | Polypropylene |
| Vent Cap | PVDF | PVDF | PVDF | PVDF | PVDF | PVDF | PVDF |
| Housing Vent | Adjustable vent with male and female Luer connections on inlet side of device | ||||||
| Filtration Area | 17.7 cm² | 17.7 cm² | 17.7 cm² | 17.7 cm² | 17.7 cm² | 17.7 cm² | 3.5 cm² |
| Maximum Inlet Pressure, bar (psi) | 5.5 bar (80 psi) @ 25 °C | 5.5 bar (80 psi) @ 25 °C | 5.5 bar (80 psi) @ 25 °C | 5.5 bar (80 psi) @ 25 °C | 5.5 bar (80 psi) @ 25 °C | 5.5 bar (80 psi) @ 25 °C | 4.1 bar (60 psi) @ 25 °C |
| Toxicity | Component materials meet the requirements of the USP Class VI Biological Test for Plastics. Capsules are also non-toxic per USP General (Mouse) Safety Test. | ||||||
| Integrity Test - Bubble Point | |||||||
| 0.22 µm | ≥3450 mbar (50 psig) air with water | ≥3450 mbar (50 psig) air with water | ≥3450 mbar (50 psig) air with water | ≥4000 mbar (58 psig) air with water | ≥4000 mbar (58 psig) air with water | ||
| 0.1 µm | ≥4830 mbar (70 psig) air with water | ≥2586 mbar (37.5 psig) nitrogen with 70/30 % IPA/water | |||||