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540211 PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem

The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV

Primary Target: SHP-2
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540211
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Tabela com principais espec.

CAS #Empirical Formula
329317-98-8C₂₆H₂₆F₆N₂O₄S₂

Preço e Disponibilidade

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540211-10MG
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      Description
      OverviewAn uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP; IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-ς, PTP-β, and PTP-µ, respectively).
      Catalogue Number540211
      Brand Family Calbiochem®
      Synonymsbis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
      References
      ReferencesHuang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.
      Product Information
      CAS number329317-98-8
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₂₆H₂₆F₆N₂O₄S₂
      Chemical formulaC₂₆H₂₆F₆N₂O₄S₂
      HS Code2935 90 99
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSHP-2
      Primary Target IC<sub>50</sub>1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      540211-10MG 04055977268676

      Documentation

      PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      540211

      Referências

      Visão geral de referência
      Huang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.

      Citações

      Título
    • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
      		•
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonymsbis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
      DescriptionAn uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC50 = 1.8 µM), PTP1B (IC50 = 2.5 µM), PTP-ε (IC50 = 8.4 µM), PTP-Meg-2 (IC50 = 13 µM), PTP-ς (IC50 = 20 µM), PTP-β (IC50 = 6.4 µM), and PTP-µ (IC50 = 6.7 µM).
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number329317-98-8
      Chemical formulaC₂₆H₂₆F₆N₂O₄S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or ACN
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHuang, P., et al. 2003. Bioorg. Med. Chem. 11, 1835.
      Citation
    • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
      		•