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PHR1187

レチノイン酸

Name: レチノイン酸
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

ATRA, オールtransレチノイン酸, トレチノイン, ビタミンA酸

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この商品について

実験式（ヒル表記法）:

C₂₀H₂₈O₂

CAS番号:

302-79-4

分子量:

300.44

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823197

EC Number:

206-129-0

Beilstein/REAXYS Number:

2057223

MDL number:

MFCD00001551

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特性

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. T1850000, traceable to USP 1674004

API family

tretinoin

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

180-181 °C (lit.)

application(s)

food and beverages

format

neat

storage temp.

-10 to -25°C

SMILES string

CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChI key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

詳細

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

Application

Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

all−transレチノイン酸 (ATRA)は、レチノイン酸受容体(RAR)とレチノイドX受容体(RXR)の両方のリガンドです。結合したRARおよびRXRは、正常細胞と腫瘍細胞の増殖や分化を制御する転写因子として機能します。チトクロムP450(CYP)は、ATRAの4-ヒドロキシル化を触媒します。レチノイン酸は、胚性幹細胞がニュ-ロンになるのを促進します。

レチノイン酸受容体(RAR)とレチノイドX受容体(RXR)の両方のリガンドで、胚性幹細胞がニュ-ロンになるのを促進します。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

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pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H315,H360FD,H410

pcodes

P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c