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Merck

A1400000

Atropine sulfate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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A propos de cet article

Formule linéaire :
(C17H23NO3)2 · H2SO4 · H2O
Numéro CAS:
5908-99-6
Poids moléculaire :
694.83
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329770705
MDL number:
MFCD00074815
Beilstein/REAXYS Number:
6109275

Principaux documents

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InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

grade

pharmaceutical primary standard

API family

atropine

manufacturer/tradename

EDQM

mp

189-192 °C (A) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Atropine sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
A I Jobling et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 696-710 (2014-11-14)
Age-related macular degeneration (AMD) is a leading cause of vision loss, characterized by drusen deposits and thickened Bruch's membrane (BM). This study details the capacity of nanosecond laser treatment to reduce drusen and thin BM while maintaining retinal structure. Fifty
M K Schultz et al.
Neurotoxicology and teratology, 44, 89-104 (2014-06-20)
The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an
N Snelder et al.
British journal of pharmacology, 171(22), 5076-5092 (2014-06-26)
Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial pressure (MAP), cardiac output (CO) and total peripheral resistance (TPR). The present investigation aims to (i) extend the previously developed model by parsing CO
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