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Merck

N0020000

Nabumetone

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-(6-Methoxy-2-naphthyl)-2-butanone

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A propos de cet article

Formule empirique (notation de Hill) :
C15H16O2
Numéro CAS:
Poids moléculaire :
228.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

SMILES string

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI key

BLXXJMDCKKHMKV-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

nabumetone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS2(5743)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nabumetone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Nonselective non-steroidal anti-inflammatory drug (NSAID)

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Consulter la Bibliothèque de documents

Kaori Matsumoto et al.
Biological & pharmaceutical bulletin, 34(5), 734-739 (2011-05-03)
The cytochrome P450 (CYP) isoforms that catalyze the oxidation metabolism of 6-methoxy-2-napthylacetic acid (6-MNA), an active metabolite of nabumetone, were studied in rats and humans. Using an extractive reversed-phase HPLC assay with fluorescence detection, monophasic Michaelis-Menten kinetics was obtained for
Solubility of triamcinolone acetonide and other anti-inflammatory drugs in silicone oil: implications for Therapeutic Efficacy.
José Carlos Pastor et al.
Retina (Philadelphia, Pa.), 28(9), 1247-1250 (2008-07-17)
R Andrew Moore et al.
The Cochrane database of systematic reviews, (4)(4), CD007548-CD007548 (2009-10-13)
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 1000 mg daily, and higher doses are not advised in older patients. There are no known systematic reviews
Neha Sethi et al.
Journal of chromatographic science, 50(2), 85-90 (2012-02-03)
High efficiency and less run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, a new separation technique, ultra-performance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method is
Lenka Nespesná et al.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 60(1), 17-24 (2011-06-10)
The study aimed to establish and validate an analytical method for the determination of nabumetone and 6-methoxy-2-naphthylacetic acid (6-MNA) in human plasma after a single therapeutic dose of the drug. Two methods based on HPLC with UV and MS detection

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