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Merck

PHR1006

D-sorbitol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

D-glucitol

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A propos de cet article

Formule empirique (notation de Hill) :
C6H14O6
Numéro CAS:
50-70-4
Poids moléculaire :
182.17
UNSPSC Code:
12352201
NACRES:
NA.24
PubChem Substance ID:
329823037
EC Number:
200-061-5
Beilstein/REAXYS Number:
1721899
MDL number:
MFCD00004708

Principaux documents

Voir toute la documentation
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Nom du produit

D-sorbitol, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. S100000
traceable to USP 1617000

vapor density

<1 (vs air)

vapor pressure

<0.1 mmHg ( 25 °C)

API family

sorbitol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

98-100 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Sorbitol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography technique.
Sorbitol may be used as an internal standard in the quantitative determination ofD-glucose in corn sugar and corn syrups using gas liquid chromatography (GLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7795 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Use of sorbitol as internal standard in determination of D-glucose by gas liquid chromatography
Alexander.J.R and Garbutt.T.J
Analytical Chemistry, 37, 303-305 (1965)
An isocratic HPLC method for the determination of sorbitol and glycerol in pharmaceutical formulations
Simonzadeh N and Ronsen B
Journal of Chromatographic Science, 50(7), 644-647 (2012)
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Arlene E Dent et al.
PloS one, 3(10), e3557-e3557 (2008-10-30)
Antibodies that impair Plasmodium falciparum merozoite invasion and intraerythrocytic development are one of several mechanisms that mediate naturally acquired immunity to malaria. Attempts to correlate anti-malaria antibodies with risk of infection and morbidity have yielded inconsistent results. Growth inhibition assays
Youngkook Kwon et al.
ChemSusChem, 6(3), 455-462 (2013-01-25)
This Full Paper addresses the electrocatalytic hydrogenation of glucose to sorbitol or 2-deoxysorbitol on solid metal electrodes in neutral media. Combining voltammetry and online product analysis with high-performance liquid chromatography (HPLC), provides both qualitative and quantitative information regarding the reaction
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