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PHR1018

Dextromethorphan HBr

certified reference material

Synonyme(s) :

Dextromethorphan hydrobromide monohydrate, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide

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A propos de cet article

Formule empirique (notation de Hill) :
C18H25NO · HBr · H2O
Numéro CAS:
6700-34-1
Poids moléculaire :
370.32
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823049
MDL number:
MFCD02173901
Beilstein/REAXYS Number:
6453793
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. D0740000, traceable to USP 1181007

API family

dextromethorphan

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Br[H].[H]O[H].[H][C@]12CCCC[C@]13CCN(C)[C@H]2Cc4ccc(OC)cc34

InChI

1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

InChI key

STTADZBLEUMJRG-IKNOHUQMSA-N

Gene Information

human ... GRIN2A(2903), SIGMAR1(10280)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dextromethorphan HBr is a cough suppressant and a mucolytic agent, widely used in the treatment of various respiratory disorders such as for the relief of non-productive cough.

Application

Dextromethorphan HBr may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using hydrophilic interaction liquid chromatographic technique and first-derivative spectrophotometry technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0713 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

Classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Spectrophotometric determination of pipazethate HCl and dextromethorphan HBr using potassium permanganate
Gouda E-FAA, et al.
International Journal of Biomedical Science : IJBS, 4(4), 294-294 (2008)
A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations.
Ali S M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(1), 158-167 (2007)
Shinn-Jong Jiang et al.
Microcirculation (New York, N.Y. : 1994), 20(2), 190-201 (2012-11-13)
This study examines the effect of Dextromethorphan (d-3-methoxy-17-methylmorphinan; DXM), a commonly used cough-suppressing drug, on the expression of VCAM-1 and ICAM-1 in human umbilical vein endothelial cells (HUVECs) stimulated with lipopolysaccharide (LPS). The effect of DXM on expression of cell
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