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Merck

PHR1242

L-Threonine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

(2S,3R)-2-Amino-3-hydroxybutyric acid

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A propos de cet article

Formule linéaire :
CH3CH(OH)CH(NH2)CO2H
Numéro CAS:
72-19-5
Poids moléculaire :
119.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823246
EC Number:
200-774-1
Beilstein/REAXYS Number:
1721646
MDL number:
MFCD00064270

Principaux documents

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Nom du produit

L-Threonine, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

InChI key

AYFVYJQAPQTCCC-GBXIJSLDSA-N

SMILES string

C[C@@H](O)[C@H](N)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. T1340000
traceable to USP 1667202

API family

l-threonine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

256 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Application

L-Threonine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

L-Threonine is an essential amino acid. It is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. L-threonine has a role in the immune system, in O-linked glycosylation, protein phosphorylation and glycine synthesis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9046 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Na Wang et al.
Cancer, 120(19), 2965-2979 (2014-06-06)
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